Table 3.

Comparison of M1 and M2 macrophage density across MRONJ stages and controls pairwise

Pairwise comparison	M1a p-valuec	M2b p-value	M1/M2 p-value
Control antiresorptive vs. Control_no antiresorptive	1.000	1.000	1.000
Control antiresorptive vs. Stage 1	0.069	0.478	0.732
Control antiresorptive vs. Stage 3	<0.001**	1.000	0.002**
Control antiresorptive vs. Stage 2	<0.001**	1.000	<0.001**
Control no antiresorptive vs. Stage 1	0.473	1.000	1.000
Control no antiresorptive vs. Stage 3	0.017*	1.000	0.016*
Control no antiresorptive vs. Stage 2	0.006**	0.805	0.002**
Stage 1 vs. Stage 3	1.000	0.199	0.357
Stage 1 vs. Stage 2	0.762	0.024*	0.049*
Stage 3 vs. Stage 2	1.000	1.00	1.000

^aCD68⁺/iNOS⁺ M1 macrophage density (cells/mm²).

^bCD68⁺/CD206⁺ M2 macrophage density (cells/mm²).

^cKruskal-Wallis Test, pairwise comparison; p-values have been adjusted by the Bonferroni correction for multiple tests.

^*p <0.05

^**p <0.01

MRONJ = Medication-Related Osteonecrosis of the Jaw.