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. Author manuscript; available in PMC: 2022 May 11.
Published in final edited form as: Biochemistry. 2020 Sep 22;60(18):1381–1400. doi: 10.1021/acs.biochem.0c00629

Scheme 4. First Asymmetric Total Synthesis of Mitragyninea.

Scheme 4.

aReagents and conditions: (a) cat. Nal, PhH, Δ; (b) NaBH4; (c) CH3C(OMe)3, cat. PhCOOH, o-xylene; (d) LDA, HCOOMe, THF, −78 °C, 30 min; (e) HCl in MeOH; (f) t-BuOK, DMF; (g) PtO2/H2, EtOH.