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. 2021 Mar 8;12:641075. doi: 10.3389/fphar.2021.641075

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Copyright © 2021 Sun, Chen, Yao, Weng, Liu and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Forest plots estimating the associations of ABCG2 rs2231142 polymorphism with sunitinib-induced toxicity and the corresponding sensitivity analysis (A allele vs. C allele). The ABCG2 rs2231142 A allele was significantly associated with an increased risk of thrombocytopenia in Asians compared with the C allele, while there were no significant associations between the A allele and C allele in hypertension, HFS, or neutropenia. The sensitivity analysis showed that no single study qualitatively altered the pooled ES of thrombocytopenia and neutropenia; however, the study by Diekstra et al. altered the hypertension results, and the study by Garcia-Donas et al. altered the HFS results.