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. 2021 Mar 8;11:629726. doi: 10.3389/fimmu.2020.629726

Figure 2.

Figure 2

Identification of specific monocyte/macrophage subtypes and their expression of PAR2 in SF of PsA, OA and RA patients. Flow cytometry was used to determine the total (A) and PAR2-expressing (B) monocytes/macrophages from SF of PsA, OA and RA patients (n=10 each). Classical (CD14+CD16-) monocytes/macrophages are elevated in RA compared to PsA (p=0.030) while intermediate (CD14+CD16+) cells are higher in PsA compared to RA (p=0.038). PAR2 expression is increased in OA compared to PsA (p=0.014) and RA (p=0.046) patients and is expressed predominantly in cells with an intermediate phenotype (p=0.008). No significant differences are observed in PAR2 expression between cell subpopulations of PsA SF cells (C). Populations were compared using the Kruskal-Wallis test with Dunn’s multiple comparisons test. Asterisks are used to indicate significant differences between groups, where *p<0.05 and **p<0.01.