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. 2021 Mar 8;11:629726. doi: 10.3389/fimmu.2020.629726

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Copyright © 2021 Abji, Rasti, Gómez-Aristizábal, Muytjens, Saifeddine, Mihara, Motahhari, Gandhi, Viswanathan, Hollenberg, Oikonomopoulou and Chandran

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Total and active tryptase-6 levels detected in SF from PsA, OA and RA patients. Total and active tryptase-6 levels were determined by a commercially available ELISA and a pull-down activity assay, respectively in PsA, OA and RA SF samples (n=10 per group). As shown in (A), total levels of tryptase-6 were elevated in RA (median 115.6 ng/ml, range 87.6-175.5) compared to OA SF (median 70.08 ng/ml, range 50.3–87.9, p=0.002, Mann Whitney U test). The activity of pulled down-tryptase-6 from PsA SF towards VPR-AMC generated the substrate cleavage curve shown in (B). Tryptase-6 activity from SF samples, after normalization to either total protein levels (C) or total tryptase-6 (D), did not reveal any significant differences between groups. Asterisks are used to indicate significant differences between groups, where **p<0.01.