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. 2021 Mar 8;11:608842. doi: 10.3389/fonc.2021.608842

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Copyright © 2021 Lu, Zheng, Gong, Lv, Chen, Tu, Lin, Pan, Guo and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The copy number variation (CNV) and methylation of HMMR in HNSCC. (A) the expression level in different CNV of HMMR (n = 514); (B) the correlation between HMMR methylation and its expression level (n = 521); (C) The methylation levels of HMMR in pan-cancer and normal tissues from TCGA data; (D) The promoter methylation of HMMR in tumor tissues (n = 528) and normal tissues (n = 50) from TCGA-HNSCC data; (E) the Kaplan–Meier survival of the promoter methylation of HMMR in HNSCC (n = 527). ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001.