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Synthesis of analog 27. Reagents and conditions: (i) l-proline methyl ester hydrochloride, T3P, DIPEA, DMF, rt, 12 h; (ii) LiOH, MeOH/H2O, rt, overnight; (iii) aniline, HATU, DIPEA, DMF, rt, 12 h; (iv) TFA; DCM, rt, 6 h; (v) HATU, DIPEA, DMF, rt, 12 h.
