Table 2.

Half-life (t_1/2, min) of selected compounds in liver microsomes.

Compd.	t1/2 (min)
	HLM	HLM (+Cobia)	MLM	MLM (+Cobia)
PF74b	0.7	91	0.6	34
10	12	>120	4.6	>120
18	15	–	3.6	–
19	22	42	5.0	34
20	36	>120	13	52
23	12	–	3.6	–
26	14	>120	2.4	28

^aMeasured in the presence of CYP3A inhibitor Cobi.

^bValues for PF74 were also reported in our previous publications^43,44. –Not applicable.