Skip to main content
. 2020 Oct 29;11(3):609–620. doi: 10.1016/j.apsb.2020.10.022

Table 1.

Clinical trials of Hedgehog pathway modulators discussed in gastrointestinal disease (data from ClinicalTrials. gov39).

Drug Target Disease indication Maximum developmental stage ClinicalTrials.gov identifier
Vismodegib (GDC-0449) SMO (antagonist) Metastatic colorectal cancer Phase II NCT00636610
Sonidegib (LDE225) SMO (antagonist) Certain cancers (including metastatic colorectal cancer, gastric cancer, gastroesophageal junction cancer) Phase I NCT01576666
Vismodegib (GDC-0449) SMO (antagonist) Advanced stomach cancer or gastroesophageal junction cancer Phase II NCT00982592
Vitamin D3 SMO (antagonist) Stage IV colorectal cancer Phase II NCT01074216
TAK-441 SMO (antagonist) Advanced nonhematologic malignancies Phase I NCT01204073
BMS-833923 SMO (antagonist) In inoperable, metastatic gastric, gastroesophageal, or esophageal adenocarcinomas Phase I NCT00909402
Curcumin GLI (antagonist) Unresectable colorectal cancer Phase II NCT02439385
Resveratrol GLI (antagonist) Colorectal cancer Phase I NCT00433576
Epigallocatechin-3-gallate GLI (antagonist) Colorectal cancer Phase I NCT02891538

SMO, Smoothened; GLI, glioma-associated oncogene homologue.