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. 2021 Mar 17;14:91–102. doi: 10.2147/CEG.S288688

Table 4.

Comparison Between Inflammatory Behavior of Crohn’s Disease without Perianal Disease (B1) and Those with Complications (Strictures, Fistulas or Perianal Disease – B2, B3 or Bxp)

CD – Inflammatory Behavior and No Perianal Disease (B1) (n=90) CD with Strictures, Fistulas or Perianal Disease (B2, B3 or Bxp) (n=213) p
Age at diagnosis (mean±SD) 33.3±16.4 31.4±13.6 0.023*
Duration of disease (mean±SD) 7.7±7.5 11.8±9.5 <0.001*
Female (n, %) 46 (51.1) 106 (49.8) 0.830
Smoking habit at diagnosis of CD (n, %) 18 (20) 53 (24.9) 0.209
Hospitalization (n, %) 53 (58.9) 192 (90.1) <0.001*
Salicylates (n, %) 84 (93.3) 183 (85.9) 0.068
Corticosteroids (n, %) 59 (65.6) 171 (80.3) 0.006*
Immunomodulators (n, %) 47 (52.2) 190 (89.2) <0.001*
Biologics (n, %) 22 (24.4) 148 (69.5) <0.001*
At least 1 IBD-related surgery (n, %) 10 (11.1) 150 (70.4) <0.001*

Notes: Quantitative variables: Student’s t-test (normal distribution); categorical variables: χ2 test; *p < 0.05= statistical significance. IBD-related surgery: CD abdominal or perianal procedures due to complications of disease;

Abbreviations: CD, Crohn’s disease; SD, standard deviation; n, number of patients; Bxp, B1, B2, or B3 with perianal disease.