Table 3.
List of miRNAs regulating angiogenesis in tumor microenvironment.
| miRNAs | Targeted signaling pathways | References | |
|---|---|---|---|
| Proangiogenic | miR-9, miR-21, miR-874, miR-16, miR-34a, miR-590-5p, miR-132, miR-296, miR-210, miR-568, miR-25-3p, miR-150, miR-499 | VEGF signaling | (57–59) |
| miR-210, miR-155, miR-21, miR-200c, miR-199 | HIF signaling | (57, 58, 60, 61) | |
| miR-375, miR-296, miR-146a | PDGF | (57, 62) | |
| miR126, miR-382, miR-26a, miR-145 | RTK signaling | (57, 62) | |
| miR-9, miR-26-3p, miR-146a-5p, miR-98, miR-181a-5p | MMP signaling | (57, 62) | |
| miR-503 | FGF signaling | (57, 62) | |
| miR-204 | Angiopoietin | (60, 61) | |
| miR-494 | Akt/eNOS pathway | (60, 61) | |
| miR-93 | Integrin-β8 | (63) | |
| Anti-angiogenic | miR-15a, miR-16, miR-29b, miR-29c, miR-128, miR-497, miR-126, miR-503, miR-204, miR-195, miR-124, miR138, miR-134, miR-107, miR-206, miR-622 | VEGF signaling | (57, 59, 61, 62) |
| miR-519c, miR-22, miR-107, miR-204, miR-128, miR-145, miR-206 | HIF signaling | (57, 61, 62) | |
| miR-125b | VE-cadherin | (57, 62) | |
| miR-29b, miR-204, miR-200c | PDGF | (57, 62) | |
| miR-21, miR-218, miR-18a, miR-145 | RTK signaling | (60, 61) | |
| miR-29b | MMP signaling | (57, 62) | |
| miR-503, miR-148b-3p | FGF signaling | (57, 62) | |
| miR-542-3p, miR-543 | Angiopoietin | (57, 62) | |
| miR-206 | Akt/eNOS pathway | (60, 61) | |
| Pro/Anti-angiogenic | miR-27b | VEGF, AMPK, Semaphorin 6A | (57, 62, 64) |
| miR-17-92 | HIF-1α, VEGF | ||
| miR-19a | MMP9, VEGF |