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. 2020 Sep 3;11(3):651–667. doi: 10.1016/j.apsb.2020.08.016

Figure 9.

Figure 9

(a) Schematics of the process of PcCLs transport through the mucus layer and epithelium. (b) 3D images of CLs and PcCLs penetration into mucus (green: formulations; red: mucus). (c) Distribution of CLs and PcCLs in small intestinal villi (green: formulations; blue: intestinal villi nuclei). Red arrows indicate the absorption points. (d) Blood glucose level-time curves of diabetic rats after administration of insulin solution (s.c. 5 IU/kg and i.j. 75 IU/kg), CLs, PcCLs and PcCLs mixed with aprotinin (i.j. 75 IU/kg; s.c.: subcutaneous; i.j.: intrajejunal). (e) Corresponding serum insulin level-time curves. Data are mean ± SD, n = 6, ∗P < 0.05 vs. CLs group. Reprinted with the permission from Ref. 171 Copyright © 2019 John Wiley and Sons Ltd.