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. 2020 Nov 28;11(3):727–737. doi: 10.1016/j.apsb.2020.11.021

Figure 1.

Figure 1

CAR activation induces hepatomegaly and increase the liver-to-body weight ratio. (A) Male C57BL/6 mice were treated by TCPOBOP for 5 or 10 days. (B) The liver-to-body weight ratio significantly increased in TCPOBOP-treated group. (C) Liver morphology also shows a liver hypertrophy. (D) H&E staining suggests that there was no liver injury. Scale bar = 50 μm. (E) CTNNB1 staining was performed to measure the cell size, which indicated an increase of cell size around CV area. Scale bar = 50 μm. (F) Quantification of CTNNB1 staining in TCPOBOP-treated mice. (G) The expression of KI67 was measured by KI67 staining, the number of KI67+ cells was increased in PV area after treated by TCPOBOP. KI67+ cells were indicated by arrows. Scale bar = 50 μm. (H) Quantification of KI67 staining in TCPOBOP-treated mice. Data are presented as mean±SD, n = 5; ∗∗P<0.01, ∗∗∗∗P<0.0001, significantly different to the control; Student's t test.