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. 2020 Nov 28;11(3):727–737. doi: 10.1016/j.apsb.2020.11.021

Figure 2.

Figure 2

CAR activation promotes liver regeneration and facilitates the restore of liver weight after partial hepatectomy. (A) Mice after partial hepatectomy were treated with TCPOBOP for 2 or 5 days. (B) The liver-to-body weight ratio was much higher in TCPOBOP-treated group. (C) Liver morphology suggested an increase of liver size. (D) H&E staining suggested that no liver injury occurred. Scale bar = 50 μm. (E) Hepatocyte size was quantified by CTNNB1 staining which showed hepatocytes hypertrophy around CV area. Scale bar = 50 μm. (F) Quantification of CTNNB1 staining in TCPOBOP-treated mice after PHx. (G) The number of KI67+ cells significantly was increased around PV area which indicated an increase of proliferative response. KI67+ cells were indicated by arrows. Scale bar = 50 μm. (H) Quantification of KI67 staining in TCPOBOP-treated mice after PHx. Data are presented as mean±SD, n = 5; ∗P<0.05, ∗∗∗P<0.001, significantly different to the control; Student's t test.