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. 2020 Nov 28;11(3):727–737. doi: 10.1016/j.apsb.2020.11.021

Figure 4.

Figure 4

CAR activation-induced hepatomegaly is partially via YAP pathway. (A) Wild-type or Yap–/– mice were treated by TCPOBOP for 10 days. (B) The liver-to-body weight ratio in TCPOBOP-treated Yap–/– mice was lower than TCPOBOP-treated wild-type mice, but was still much higher than vehicle group of Yap–/– mice. (C) Liver morphology suggested that liver size was increased even in Yap–/– mice. (D) H&E staining suggested that no liver injury occurred. Scale bar = 50 μm. (E) CTNNB1 staining showed that there was still a slight increase of hepatocytes size around CV area in Yap–/– mice. Scale bar = 50 μm. (F) Quantification of CTNNB1 staining in wild-type or Yap–/– mice. (G) The number of KI67+ cells still was increased in Yap–/– mice around PV area. KI67+ cells were indicated by arrows. Scale bar = 50 μm. (H) Quantification of KI67 staining in wild-type or Yap–/– mice. Data are presented as mean±SD, n = 5; ∗P<0.05, ∗∗P<0.01, ∗∗∗∗P<0.0001, significantly different to the control; Student's t test.