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. 2020 Oct 31;11(3):750–762. doi: 10.1016/j.apsb.2020.10.021

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© 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Assay performance and correlation analysis. (A) Assay performance and correlation analysis of 302 compounds tested at 10 μmol/L in SHP2-WT enzyme assay. Data represented by inhibition rate were obtained from two independent experiments. (B) Correlation analysis of two cross-validation high-throughput screening assays through a panel of hit compounds derived from subsequent screening of our in-house compound library. Red dots represent active site inhibitors identified from SHP2-PTP enzyme assay. Black dots represent allosteric site inhibitors cross-validated through SHP2-WT enzyme assay and thermal shift assay.