Fig. 1.

Sources of energy expenditure adipocytes and expected effects of their transplantation on metabolic health. Left part: iPSCs can be generated from patients. An iPSC colony and an iPSC-derived 3D vascularized adiposphere expressing perilipin 1 (red), UCP1 (green), and CD31 (white) are shown. Right part: A biopsy of subcutaneous white adipose tissue can be converted ex vivo in beige adipose tissue expressing UCP1 (green). Lipid droplets were staining with Oil Red O. Images showed in the figure originate from projects developed in Dani’s group