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. 2021 Mar 8;15:600462. doi: 10.3389/fnins.2021.600462

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Copyright © 2021 Shen, Wang, Chen and Wong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hierarchical clustering for DE-miRNAs (A) and DE-piRNAs (B) of mutant/transgenic strains compared with WT strain. The cutoff of DE-miRNAs was p < 0.05 and absolute fold change >2; DE-piRNAs were p < 0.01, FDR < 0.1, and absolute fold change >2. The logarithmic scale represents the range of expression values of DE-miRNAs/DE-piRNAs. The top cluster dendrogram indicates the similarity of different strains based on the average expression values of all DE-miRNAs/DE-piRNAs of each strain. The left cluster dendrogram indicates the similarity of different DE-miRNAs/DE-piRNAs based on the average expression values of each DE-miRNA/DE-piRNA of all strains. The right colored bars show the DE-miRNA/DE-piRNA expression values.