Table 3.

Frequency of treatment-related grade ≥3 adverse events (AE).

Variable	cohort A (n = 252)		cohort B (n = 298)		P-value*
Hematologic toxicities, n (%)
Any	67	(27)	91	(31)	0.355
Neutropenia	50	(20)	63	(21)	0.674
Anemia	13	(5)	33	(11)	0.019
Thrombocytopenia	12	(5)	13	(4)	0.985
Non-hematologic toxicities, n (%)
Any	65	(26)	80	(27)	0.856
Fatigue	3	(1)	12	(4)	0.076
Anorexia	4	(2)	24	(8)	0.001
Febrile neutropenia	3	(1)	6	(2)	0.674
Hand-foot skin reaction	32	(13)	12	(4)	<0.001
Liver dysfunction	14	(6)	14	(5)	0.794

^*P-values were calculated by Fisher's exact probability test for categorical variables.

AE, adverse event.