Table 3.
The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of miR-21-3p downstream targets (top 12 listed here).
| #Term | ID | Input number | Background number | P-Value | Corrected P-Value |
|---|---|---|---|---|---|
| Metabolic pathways | hsa01100 | 28 | 1243 | 0.0068 | 0.0303 |
| Pathways in cancer | hsa05200 | 14 | 397 | 0.001 | 0.0110 |
| MAPK signaling pathway | hsa04010 | 12 | 255 | 0.0003 | 0.0063 |
| PI3K-Akt signaling pathway | hsa04151 | 12 | 342 | 0.0030 | 0.0173 |
| cGMP-PKG signaling pathway | hsa04022 | 11 | 167 | 2.89E-05 | 0.0016 |
| Ubiquitin mediated proteolysis | hsa04120 | 10 | 137 | 2.93E-05 | 0.0016 |
| Insulin signaling pathway | hsa04910 | 10 | 139 | 3.29E-05 | 0.0016 |
| Hippo signaling pathway | hsa04390 | 10 | 154 | 7.42E-05 | 0.0022 |
| cAMP signaling pathway | hsa04024 | 10 | 199 | 0.0005 | 0.0085 |
| HTLV-I infection | hsa05166 | 10 | 259 | 0.0034 | 0.01838 |
| TGF-beta signaling pathway | hsa04350 | 6 | 84 | 0.0013 | 0.0110 |
| mTOR signaling pathway | hsa04150 | 7 | 154 | 0.0060 | 0.0269 |