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Model of TGF‐β3 from prostate CAFs with MPSSS treatment regulating the cell cycle of PC‐3 cells. TGF‐β3 from MPSSS‐treated prostate CAFs is upregulated and leads to the formation of the smad3—smad4 complex. This complex interacts with FoxO protein to activate p21 and arrest the PC‐3 cells in G0/G1 phase
