FIGURE 7.

MiR‐125b‐2‐3p overexpression restores the sensitivity of drug‐resistant colorectal cancer cells. (A) Western blot of MDR1 in the total lysates of HCT8 normal cells and drug‐resistant cells. (B) MTS assays show the viability of HCT8 normal cells and HCT8 drug‐resistant cells exposed to 5‐fluorouracil (72 h). (C) Images (left panel) and quantification (right panel) of apoptosis assays of the indicated cells cultured with 692 μM or 4,000 μM 5‐fluorouracil for 2 days. (D) Western blot of MDR1 in the total lysates of HCT116 normal cells and drug‐resistant cells. (E) MTS assays show the viability of HCT116 normal cells and HCT116 drug‐resistant cells exposed to oxaliplatin (72 h). (F) Images (left panel) and quantification (right panel) of the apoptosis assays of the indicated cells cultured with 25 μM or 60 μM oxaliplatin for 2 days. Data are presented as the mean ± SD. (n = 3). ^* p < 0.05 or ^** p < 0.01 versus the control