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. 2021 Mar 8;10(7):2470–2481. doi: 10.1002/cam4.3830

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© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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MCM3AP‐AS1 knockdown suppressed CRC cell migration and invasionin vitro and metastasis in vivo. (A, B) The effects of MCM3AP‐AS1 knockdown on the migration and invasion of HCT‐8 (A) and LoVo (B) cells were detected by transwell assays. (C) MCM3AP‐AS1 knockdown inhibited CRC metastasis. LoVo cells with MCM3AP‐AS1 knockdown were injected to the tail veins of nude mice (n = 5) to evaluated the function of MCM3AP‐AS1 in a lung metastasis mouse model. Representative HE‐stained sections of lung tissues are showed in this panel. The number of lung nodules were quantified after dissection. **p < 0.01, ***p < 0.001.