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. 2021 Mar 8;10(7):2470–2481. doi: 10.1002/cam4.3830

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© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The protein expression of SENP1 was up‐regulated in CRC tissues compared with paired NCTs and positively correlated with the MCM3AP‐AS1 expression. (A) Immunohistochemistry staining of SENP1 in CRC tissues and NCTs. (B) The percentage of upregulated, downregulated and unchanged SENP1 in 102 paired CRC tissues and NCTs. (C) Bivariate correlation analysis between MCM3AP‐AS1 and SENP1 expression in CRC tissues. (D) Kaplan‐Meier survival analysis based on the scores of SENP1 protein expression. (E) The mRNA expression levels of SENP1 of CRC in TCGA database. (F) Bivariate correlation analysis between MCM3AP‐AS1 and SENP1 expression of CRC in TCGA database. ****p < 0.0001.