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. 2021 Mar 8;10(7):2470–2481. doi: 10.1002/cam4.3830

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© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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MCM3AP‐AS1 exerted its oncogenic role through the MCM3AP‐AS1/miR‐193a‐5p/SENP1 axis. (A) The protein levels of SENP1 were determined in LoVo cells with stable MCM3AP‐AS1 silencing after transfected with pcDNA3.1‐SENP1 by western blotting. (B, C) The rescuing effects of SENP1 on the decreased proliferation (B) and migration (C) induced by MCM3AP‐AS1 knockdown were detected by CCK8 and transwell assays. (D) The protein levels of SENP1 were determined in LoVo cells with stable MCM3AP‐AS1 silencing after transfected with miR‐193a‐5p inhibitor by western blotting. (E, F) miR‐193a‐5p inhibitor rescued the proliferation (E) and migration‐inhibiting (F) effects of MCM3AP‐AS1 knockdown. *p < 0.05, **p < 0.01, ***p < 0.001.