FIGURE 2.

CFL1 promotes the proliferation and invasion of HCC cells. (A) HCCLM3 and MHCC97H cells that were transfected with nontargeting (NT) shRNA or CFL1 shRNAs (shRNA2 and shRNA3) were subjected to western blotting for CFL1, E‐cadherin, N‐cadherin, and Vimentin expression. (B) CFL1 knockdown repressed the viability of HCC cells. (C) CFL1 silencing suppressed the proliferation of HCC cells. (D) HCC cell migration and invasion were reduced by CFL1 knockdown in vitro. (E) Hep3B cells that were transfected with negative control (NC) or CFL1 overexpression plasmid (OE) were subjected to western blotting for CFL1, E‐cadherin, N‐cadherin, and Vimentin expression. (F) CFL1 overexpression promoted the viability of Hep3B cells. (G) Ectopic expression of CFL1 enhanced the proliferation of Hep3B cells. (H) The migration and invasion abilities of Hep3B cells were increased by CFL1 overexpression in vitro. *p < 0.05