TABLE 2.
Univariate and multivariate Cox hazard analysis of clinical features associated with overall survival in hepatocellular carcinoma patients
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Clinical variables | HR | 95% CI | p value | HR | 95% CI | p value |
| Age (≥50 vs. <50) | 1.699 | 0.864‐3.339 | 0.124 | – | – | – |
| Gender (male vs. female) | 1.642 | 0.942‐2.862 | 0.080 | – | – | – |
| Tumour size (≥5 vs. <5 cm) | 1.717 | 1.003‐2.938 | 0.049* | 1.534 | 1.087‐2.165 | 0.015* |
| Tumour number (≥2 vs. 1) | 3.489 | 1.631‐7.465 | 0.001* | 2.370 | 1.479‐3.799 | <0.001* |
| Edmondson stage (III+IV vs. I+II) | 1.486 | 0.452‐4.881 | 0.514 | – | – | – |
| TNM stage (III+IV vs. I+II) | 3.671 | 1.743‐7.732 | 0.001* | 1.510 | 0.938‐2.429 | 0.09 |
| Venous infiltration (present vs. absent) | 1.839 | 1.069‐3.164 | 0.028* | 1.677 | 1.174‐2.397 | 0.005* |
| Serum AFP level (≥20 vs. <20 ng/ml) | 1.250 | 0.760‐2.056 | 0.380 | – | – | – |
| Cirrhosis (present vs. absent) | 0.629 | 0.360‐1.096 | 0.102 | – | – | – |
| HBV infection (present vs. absent) | 1.820 | 1.053‐3.146 | 0.032* | 1.534 | 1.134‐2.823 | 0.085 |
| CFL1 level (high vs. low) | 2.268 | 1.309‐3.930 | 0.003* | 1.505 | 1.025‐2.211 | 0.037* |
Abbreviations: CI, confidence interval; HR, hazard ratio.
*
Indicates statistically significant.