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. 2021 Mar 8;12:627623. doi: 10.3389/fgene.2021.627623

TABLE 4.

Top enriched bovine respiratory disease (BRD) differentially expressed (DE) genes in Cluster A compared with Clusters B and C.

Gene name Gene description LogFC P-Adjust
CATHL2 Cathelicidin 2 [Source: NCBI gene; Acc: 282165] 8.91 1.03E-33
CD177 CD177 molecule [Source: VGNC Symbol; Acc: VGNC:27006] 8.35 1.17E-34
CATHL6 Cathelicidin 6 [Source: NCBI gene; Acc: 317651] 7.71 2.28E-33
CATHL3 Cathelicidin 1 [Source: NCBI gene; Acc: 282164] 7.37 2.77E-26
CATHL5 Cathelicidin 5 [Source: NCBI gene; Acc: 282167] 7.04 1.48E-28
NGP Neutrophilic granule protein-like [Source: NCBI gene; Acc: 788112] 5.77 1.12E-13
LTF Lactotransferrin [Source: VGNC Symbol; Acc: VGNC:31077] 5.57 1.01E-30
MS4A3 Membrane spanning 4-domains A3 [Source: VGNC Symbol; Acc: VGNC:58392] 5.54 1.49E-16
EBD Enteric beta-defensin [Source: NCBI gene; Acc: 281743] 5.42 4.90E-20
ORM1 Orosomucoid 1 [Source: NCBI gene; Acc: 497200] 5.10 2.85E-23
DEFB4A Defensin, beta 4A [Source: NCBI gene; Acc: 286836] 5.01 4.34E-20
PGLYRP1 Peptidoglycan recognition protein 1 [Source: VGNC Symbol; Acc: VGNC:32791] 5.01 6.43E-29
MMP8 Matrix metallopeptidase 8 [Source: VGNC Symbol; Acc: VGNC:31530] 5.00 2.50E-18
CCL14 Chemokine (C-C motif) ligand 14 [Source: NCBI gene; Acc: 616723] 4.57 1.16E-22
FLT4 fms related tyrosine kinase 4 [Source: VGNC Symbol; Acc: VGNC:29044] 4.51 9.30E-13
EFNB2 Ephrin B2 [Source: VGNC Symbol; Acc: VGNC:28360] 4.34 2.04E-23
IL1R2 Interleukin 1 receptor type 2 [Source: VGNC Symbol; Acc: VGNC:30132] 4.32 8.21E-16
MMP27 Matrix metallopeptidase 27 [Source: VGNC Symbol; Acc: VGNC:54886] 4.25 8.38E-08
RETN Resistin [Source: VGNC Symbol; Acc: VGNC:33877] 4.13 1.63E-18
FOLR3 Folate receptor 3 [Source: NCBI gene; Acc: 516067] 4.07 6.08E-07
HSPG2 Heparan sulfate proteoglycan 2 [Source: VGNC Symbol; Acc: VGNC:29988] 3.82 2.72E-22
LCN2 Lipocalin 2 [Source: VGNC Symbol; Acc: VGNC:30814] 3.75 6.71E-18
MMP9 Matrix metallopeptidase 9 [Source: VGNC Symbol; Acc: VGNC:31531] 3.65 2.20E-12
TMEM217 Transmembrane protein 217 [Source: VGNC Symbol; Acc: VGNC:36039] 3.53 2.21E-16
LBP Lipopolysaccharide-binding protein [Source: VGNC Symbol; Acc: VGNC:56192] 3.48 4.27E-10
RAB3IL1 RAB3A interacting protein like 1 [Source: VGNC Symbol; Acc: VGNC:33655] 3.46 2.11E-09
ALOX5 Arachidonate 5-lipoxygenase [Source: VGNC Symbol; Acc: VGNC:25844] 3.34 3.28E-13
SERPINB2 Serpin family B member 2-like [Source: NCBI gene; Acc: 281376] 3.29 7.61E-11
BPI Bactericidal permeability increasing protein [Source: NCBI gene; Acc: 280734] 3.20 6.12E-08
CCL24 C-C motif chemokine ligand 24 [Source: VGNC Symbol; Acc: VGNC:26950] 3.18 5.34E-10
ITGA9 Integrin subunit alpha 9 [Source: VGNC Symbol; Acc: VGNC:30320] 3.18 4.25E-13
RGL1 Ral guanine nucleotide dissociation stimulator like 1 [Source: VGNC Symbol; Acc: VGNC:33903] 3.13 1.13E-19
EREG Epiregulin [Source: VGNC Symbol; Acc: VGNC:28575] 3.11 6.57E-12
SERPINB4 Bos taurus serpin peptidase inhibitor, clade B like (LOC786410), mRNA. [Source: RefSeq mRNA; Acc: NM_001206713] 3.07 1.15E-06