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. 2021 Mar 8;12:625562. doi: 10.3389/fmicb.2021.625562

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Copyright © 2021 Jang, Son, Kim, Jung, Choi, Kim, Lee, Shin and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Viability test and Inhibitory effect of nitric oxide (NO) production of host cells. The viability changes in RAW 264.7 (upper) and DH82 (lower) cells by the bacterial strains were determined using WST-1 assay. A significant difference between the reference strain (LGG, Lactobacillus rhamnosus GG ATCC53103) and negative control (bacterial media only) (A) was determined. The inhibitory effect of NO production in RAW 264.7 (upper) and DH82 (lower) cells by the bacterial strains were detected using Greiss assay. A significant difference between the reference strain (LGG, Lactobacillus rhamnosus GG ATCC53103) and the LPS-stimulated control including bacterial media only was determined (B). Significant differences between each of CACC517, CACC537, CACC558, and CACC566 and the reference strain were determined. ^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001.