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. 2021 Mar 8;12:625346. doi: 10.3389/fimmu.2021.625346

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Copyright © 2021 Vogel, Lazennec, Kado, Dahlem, He, Castaneda, Ishihara, Vogeley, Rossi, Haarmann-Stemmann, Jugan, Mori, Borowsky, La Merrill and Sweeney.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Whole-mounted mammary glands and lungs from PyMT/wt and PyMT/AhRR⁺ mice. Virgin mammary glands from 5-month-old (A) PyMT/wt and (B) PyMT/AhRR⁺ transgenic female mice. Whole-mounts were spread on slides, fixed and stained with hematoxylin in order to elucidate ductal structure. Mammary glands from 5-month-old PyMT/wt mice compared with a tumor free PyMT/AhRR⁺ transgenic female mice are shown. Arrows indicate MT (mammary tumors) and intramammary LN (lymph node). Overexpression of AhRR in PyMT mice suppressed lung metastasis in PyMT mice. Whole-mounted lungs from (C) PyMT/wt and (D) PyMT/AhRR⁺ mice at 5 months after birth. Whole mounts were spread on slides, fixed and stained with hematoxylin in order to elucidate metastatic lung tumors (Mets) as indicated. (E) Percentage of 10 PyMT/wt and PyMT/AhRR⁺ mice with lung metastasis at necropsy. Fisher's exact test was applied and value was statistically significant different, *P = 0.0108.