Table 1.

Therapeutic targets of neutrophils in liver diseases.

Neutrophils in liver diseases pathology	Disease examples	Therapeutic way	Therapeutic targets	References
Insufficient function of neutrophils	HCC, ALD	Enhancement the function of neutrophils	Adding G-CSF	(46, 47)
Excessive function of neutrophils	LIR, APAP, NAFLD, acute and chronic liver injury (CCl4), ALD, HCC	Inhibition of neutrophils function	Targeting neutrophils NETs, blocking the signal transduction, targeting NE, targeting CXCR2-FPR1, inhibiting neutrophils recruitment, adding GR-1 antibody	(10, 22–24, 35, 36, 48–51)
Abnormal and pathogenic function of neutrophils	Acute and chronic liver injury, HCC	Restore the neutrophils function	Inhibiting CCRK or hepatic IL-6	(52, 53)

G-CSF, granulocyte colony-stimulating factor; FPR1, formyl peptide receptor 1; CCRK, cell cycle-related kinase.