Inclusion criteria | Exclusion criteria |
---|---|
(i) Age between 50 and 85 years | (i) Clinical PDD diagnosis or outcomes in the Pill-Questionnaire indicating caregiver dependency |
(ii) PD diagnosis according to the UK Brain Bank Criteria | (ii) Depression (operationalized with Beck Depression Inventory II ≥20 points) |
(iii) Self-reported cognitive impairment assessed with the Subjective Cognitive Impairment questionnaire and/or objective cognitive impairment assessed with the Montreal Cognitive Assessment <26 points | (iii) Acute suicide tendency |
(iv) PD-MCI according to Movement Disorders Society (MDS) task force Level-II criteria | (iv) Severe comorbidities affecting life expectancy, medication, or quality of life |
(v) At least 1 year since PD diagnosis | (v) Severe fatigue |
(vi) Stable medication within 4 weeks before screening | (vi) Prominent impulse control disorder or dopamine dysregulation syndrome |
(vii) Written informed consent | (vii) Acute psychosis or psychotic episode in the last 6 months before study participation |
(viii) Dementia medication | |
(ix) Participation in other treatment studies within the last 2 months before study participation | |
(x) Deep brain stimulation | |
(xi) Pregnancy or nursing period |