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. 2021 Mar 8;12:640137. doi: 10.3389/fneur.2021.640137
Inclusion criteria Exclusion criteria
(i) Age between 50 and 85 years (i) Clinical PDD diagnosis or outcomes in the Pill-Questionnaire indicating caregiver dependency
(ii) PD diagnosis according to the UK Brain Bank Criteria (ii) Depression (operationalized with Beck Depression Inventory II ≥20 points)
(iii) Self-reported cognitive impairment assessed with the Subjective Cognitive Impairment questionnaire and/or objective cognitive impairment assessed with the Montreal Cognitive Assessment <26 points (iii) Acute suicide tendency
(iv) PD-MCI according to Movement Disorders Society (MDS) task force Level-II criteria (iv) Severe comorbidities affecting life expectancy, medication, or quality of life
(v) At least 1 year since PD diagnosis (v) Severe fatigue
(vi) Stable medication within 4 weeks before screening (vi) Prominent impulse control disorder or dopamine dysregulation syndrome
(vii) Written informed consent (vii) Acute psychosis or psychotic episode in the last 6 months before study participation
(viii) Dementia medication
(ix) Participation in other treatment studies within the last 2 months before study participation
(x) Deep brain stimulation
(xi) Pregnancy or nursing period