Figure 1.

Schematic diagram of MSI2 isoforms, molecular domains and interactions. The N-terminal and C-terminal of MSI2b are different from those of MSI2a. The RRM1 motif of MSI2c is close to the N-terminal, and the C-terminal is 18 aa more than that of MSI2a. MSI2d harbors the same N-terminal as MSI2a and the same C-terminal as MSI2b. All isoforms harbor RRM1 and RRM2 domains, which recognize 3ʹ-UTR of target mRNAs, as well as a PABP interaction domain that may regulate translation initiation through binding to PABP. The arrows represent interactions.

Abbreviations: aa, amino acids; CDS, coding regions; Poly A, polyadenylate; UTR, untranslated region.