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. 2021 Mar 8;12:636289. doi: 10.3389/fimmu.2021.636289

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Copyright © 2021 Clarke, Rebman, Bailey, Wojciechowicz, Jenkins, Evangelista, Danieletto, Fan, Eshoo, Mosel, Robinson, Ramadoss, Bobe, Soloski, Aucott and Ma'ayan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Cell-type ratios were derived from gene expression with CIBERSORT. Green bar denotes Lyme disease patients. (B–D) Cell-types ratios with significant differences across all visits in healthy patients (type_subject = 0) vs. those with Lyme disease (type_subject = 1) Significance computed with Welch's unequal variance t-test for independence. (E) Predicted levels of Tregs at each visit for each cluster based on CIBERSORT LM22. (F) Comparing the identified DEGs between cases and control and early and late time-points. Enrichment analysis with Enrichr was applied to the unique genes that are only up early (left), or only down (dn) late (right) with the gene ontology biological processes gene set library.