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. 2021 Mar 8;15:648556. doi: 10.3389/fnhum.2021.648556

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Copyright © 2021 Jenkins, Khodaparast, O’Leary, Washburn, Covalin and Badran.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Roo™ therapy system. (A) The clinician application connects an iOS device to the patient controller using bluetooth low energy. The application allows a clinician to start a communication session with a Patient Controller to adjust therapy parameters, view diagnostic logs, and event history. (B) The Patient Controller delivers electrical stimulation to the earpiece via a removable cable. Clinicians can modulate therapy intensity by pressing up/down buttons and check therapy status with LED lights. (C) The earpiece (skin-facing side) delivers electrical stimulation via four metallic electrodes covered in hydrogel and surrounded with adhesive hydrocolloid (black region). (D) Hypothesized auricular dermatomes. ATN, auriculotemporal nerve; ABVN, auricular branch of the vagus nerve; GAN, greater auricular nerve. Modified from Butt et al. (2020). (E) The Roo system provides stimulation in a bipolar configuration forming stimulation channels/circuits between pairs of electrodes. The system has two channels: Channel 1 is formed between the electrode in Region 1 (ABVN) and the lower electrode in Region 3, and Channel 2 is formed between the electrode in Region 2 (ATN) and the upper electrode in Region 3. (F) Roo system on a neonate.