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. 2021 Mar 8;12:631102. doi: 10.3389/fphar.2021.631102

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Copyright © 2021 Gan, Su, Su, Wu, Chen, Han and Xiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative imaging wound healing in mouse incision wound model and rat thermal burn wounds model, and the wound contraction quantification in the thermal burn wounds model. (A) Wound healing in mouse incision wound model. The healing process was observed and photographed on the 1st, 5th, 10th, and 16th day. The control group (Con) and the treatment group (BO), which were observed 3 times per day for 16 days (n = 10 each group). Representative pictures revealing that BO pretreatment accelerate the healing process of incision wound. (B) Rats thermal burn wounds model. The process of healing was followed and photographed at intervals of the 1st, 7th, 14th, and 28th day for the negative control group (Con), the treatment group (BO), and the positive group burn moisturizing scald (BMS), with 3 times/day for 28 days (n = 12 each group). Representative pictures revealing that BO pretreatment accelerate the healing process of thermal burn wounds. (C) The percentage of thermal wound contraction. BO pretreatment enhanced wound contraction observed in the rat thermal burn wounds model. The data were expressed as the mean ± SEM (n = 12 each group), compared with the control group, *p < 0.05, **p < 0.01.