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. 2021 Mar 5;8:606197. doi: 10.3389/fvets.2021.606197

Table 4.

The effects of the nutraceutical treatment on the relative expression (fold change) of canine AD marker genes on DH82 monocytes.

DH82
Time	4 h				8 h
Inflamed	No		Yes		No		Yes
Mix	No	Yes	No	Yes	No	Yes	No	Yes
ccl2	1.01 ± 0.21	0.37 ± 0.06	3.52 ± 0.61^a	1.92 ± 0.11^b^,^c	1.17 ± 0.16	0.27 ± 0.03	2.60 ± 0.71^a^,^b^,^e	1.80 ± 0.12
ccl5	0.98 ± 0.14	1.63 ± 0.24	35.89 ± 4.94^a	36.31 ± 1.69^a^,^b	0.99 ± 0.2	1.75 ± 0.19	27.91 ± 1.45^a^,^b^,^c^,^e	30.34 ± 1.03^a^,^d^,^e
ccl17	0.95 ± 0.24	0.72 ± 0.09	17.06 ± 3.06^a	3.27 ± 0.12	1.40 ± 0.22	0.79 ± 0.14	39.90 ± 4.48^a^,^b^,^c^,^e	3.98 ± 0.83^f
tslp	1.03 ± 0.25	1.14 ± 0.23	3.30 ± 0.64^a	3.30 ± 0.79^a^,^b	0.94 ± 0.28	1.01 ± 0.12	1.69 ± 0.09^c	1.65 ± 0.11^d
il31r	0.97 ± 0.32	1.69 ± 0.24	10.45 ± 0.52^a	4.90 ± 1.72^a^,^b^,^c	1.04 ± 0.13	0.44 ± 0.1	4.41 ± 1.14^a^,^b^,^c^,^e	3.45 ± 0.56^a^,^e
ctss	1.02 ± 0.2	1.20 ± 0.34	3.58 ± 0.53^a	3.42 ± 0.43^a^,^b	0.98 ± 0.14	1.29 ± 0.54	3.21 ± 1.02^a^,^b^,^e	3.38 ± 0.84^a^,^e
il4r	1.03 ± 0.3	1.20 ± 0.72	1.66 ± 0.53	1.43 ± 0.19	1.06 ± 0.17	1.13 ± 0.59	0.90 ± 0.19	1.02 ± 0.17
il31	1.03 ± 0.11	0.87 ± 0.35	1.22 ± 0.1	1.15 ± 0.05	1.19 ± 0.16	1.36 ± 0.18	1.59 ± 0.05^a^,^b	1.36 ± 0.07

^a

p < 0.05 vs. no inflamed 4 h no mix 4 h;

^b

p < 0.05 vs. no inflamed 4 h yes mix 4 h;

^c

p < 0.05 vs. yes inflamed 4 h no mix 4 h;

^d

p < 0.05 vs. yes inflamed 4 h yes mix 4 h;

^e

p < 0.05 vs. no inflamed 8 h no mix 8 h;

^f

p < 0.05 vs. yes inflamed 8 h no mix 8 h.