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. 2021 Mar 8;12:525145. doi: 10.3389/fphys.2021.525145

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Copyright © 2021 Xu, Pan, Li, Zhang, Yan, Anwaier, Wang, Yan, Fan, Li and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of post-treatment with BHG or KW on rat estrous cycle. (A) Representative depictions illustrating the changes of estrous cycle in Control (a), DHEA (7 weeks) (b), DHEA + BHG (0.75 g/kg) (c), DHEA + BHG (1.49 g/kg) (d), DHEA + BHG (2.99 g/kg) (e), DHEA + KW (0.46 g/kg) (f), DHEA + KW (0.91 g/kg) (g), and DHEA + KW (1.82 g/kg) (h) group, respectively. P, preoestrus; E, estrus; M, metaoestrus; DI, diestrus. (B) Statistical result of the percentage of rats with normal estrous cycle after treatment with BHG or KW for 1, 2, 3, and 4 weeks. Results are presented as mean ± SEM. *P < 0.05 vs. Control group; ^†P < 0.05 vs. DHEA (7 weeks) group, n = 15.