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. 2021 Mar 8;12:525145. doi: 10.3389/fphys.2021.525145

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Copyright © 2021 Xu, Pan, Li, Zhang, Yan, Anwaier, Wang, Yan, Fan, Li and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of post-treatment with BHG or KW on follicle development of the ovary. (A) Representative HE stained images of rat ovarian tissue (a1, a2). Shown on right side are the representative images of primordial follicle (b1), primary follicle (b2), secondary follicle (b4), antral follicle (b5), cystic follicle (b6), and corpus luteum (b3), respectively. (B) Statistical result of the percentage of the follicles in different development stages and the number of corpus luteum in various groups. Results are presented as mean ± SEM. *P < 0.05 vs. Control group; ^#P < 0.05 vs. DHEA (3 weeks) group; ^†P < 0.05 vs. DHEA (7 weeks) group, n = 15.