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. 2021 Mar 8;12:525145. doi: 10.3389/fphys.2021.525145

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Copyright © 2021 Xu, Pan, Li, Zhang, Yan, Anwaier, Wang, Yan, Fan, Li and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of KW post-treatment on ER stress. (A–H) Presented are the representative western blotting images of GRP78, CHOP, ATF6, phosphorylation-inositol-requiring enzyme 1(p-IRE1), IRE1, XBP1s, phosphorylation-proline-rich receptor-like protein kinase (p-PERK), PERK, phosphorylation- eukaryotic translation initiation factor 2α (p-eIF2α), eIF2α, and ATF4 with the quantification showing below. Results are presented as mean ± SEM. *P < 0.05 vs. Control group; ^#P < 0.05 vs. DHEA (3 weeks) group; ^†P < 0.05 vs. DHEA (7 weeks) group, n = 8 for western blot.