Table 1.

Forward Selection-Partial Least Squares (FS-PLS) signatures for (A) TB/LTBI and (B) TB/OD.

Gene symbol and name*	Illumina Probe ID	Direction of regulation*
A
GBP6 Guanylate Binding Protein Family Member 6	ILMN_1756953	Up
TMCC1 Transmembrane and Coiled-Coil Domain Family 1	ILMN_1677963	Down
PRDM1 PR/SET Domain 1	ILMN_2294784	Up
ARG1 Arginase 1	ILMN_1812281	Down
*In patients with TB compared to OD.
Gene symbol and name*	Illumina Probe ID	Direction of regulation*
B
FCGR1A Fc Fragment of IgG Receptor Ia	ILMN_2176063	Up
ZNF296 Zinc Finger Protein 296	ILMN_1693242	Down
C1QB Complement C1q B Chain	ILMN_1796409	Up

^*In patients with TB compared to LTBI.

These were taken forward for further characterization and validation using dPCR, and subsequently development as diagnostic biomarkers for TB. Gene names are according to HUGO Gene Nomenclature Committee. LTBI, Latent TB infection; OD, other diseases.