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. 2021 Mar 5;9:595754. doi: 10.3389/fcell.2021.595754

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Copyright © 2021 Dapergola, Menegazzi, Raabe and Hovhanyan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of the circadian clock and light on neuroblast division rates. (A) The number of metaphase NB in relation to the overall NB number was determined in 1st, 2nd, and 3rd instar larval (IL) central brains. Compared to wild type (LD), the DD condition and the per⁰¹ mutant caused a significant reduction of dividing NBs only in 3rd instar larval brains (^∗p < 0.01, ^∗∗p < 0.001). (B) The number of metaphase NBs in 3rd instar larval brains was further decreased when per⁰¹ larvae were kept in DD (^∗∗∗p < 0.0001). At least 16 brains were analyzed for each larval stage and experimental condition.