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. 2021 Mar 5;9:642437. doi: 10.3389/fcell.2021.642437

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Copyright © 2021 Zhu, Sun, Zhu, Zou and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between TNF-α and m6A modification in IVDD patients. (A) The m6A level and expression of (B) METTL3, (C) METTL14, (D) WTAP, and (E) TNF-α in normal controls and IVDD patients. (F–I) Pearson correlation scatter plots in IVDD patients (n = 30). (J) The m6A level and (K,L) expression of METTL14 in HNPCs treated with different doses of TNF-α. *P < 0.05, **P < 0.01, ***P < 0.001 compared with normal control; ^###P < 0.001 compared with low grade; ^Δ P < 0.05, ^ΔΔ P < 0.01 compared with moderate grade.