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METTL14 silencing inhibits TNF-α-induced cell cycle arrest and senescence. (A,B) Expression of METTL14 in HNPCs transduced with METTL14 shRNA vectors. (C) Cell viability, (D,E) cell cycle, and (F) SA-β-gal staining of HNPCs transduced with METTL14 shRNA vectors and treated with 30 ng/mL TNF-α for 24 h. Scale bar: 50 μm. **P < 0.01, ***P < 0.001 compared with control; ###P < 0.001 compared with TNF-α + shNC.
