Table 2.

Impact of stroke severity on difference in protein expression between intracranial and systemic blood

Protein panel	Original fold change		Adjusted fold change			NIHSS score at admission significance
	NPXi-NPXs	P value	NPXi-NPXs	% Change*	P value	Slope estimate	P value
Cardiometabolic
FAP	−0.2604	<0.0001	−0.2604	0.00%	0.0001	−0.0072	0.3955
PLTP	−0.2647	0.0005	−0.2647	0.00%	0.0006	0.0012	0.9018
FETUB	−0.3136	0.0023	−0.3136	0.00%	0.0028	−0.0034	0.8104
UMOD	−0.1437	0.0020	−0.1437	0.00%	0.0024	−0.0030	0.6362
FCN2	−0.4628	0.0045	−0.4628	0.00%	0.0053	0.0076	0.7375
SOD1	0.3290	0.0548	0.3290	0.00%	0.0601	−0.0043	0.8631
Inflammatory
CCL19	−0.5111	<0.0001	−0.4358	−14.73%	<0.0001	−0.0186	0.1261
CCL20	−0.4034	<0.0001	−0.3483	−13.66%	<0.0001	−0.0137	0.1839
FGF21	−0.3687	0.0002	−0.3114	−15.54%	<0.0001	−0.0122	0.2035
TGFα	−0.2839	0.0002	−0.2422	−14.69%	<0.0001	−0.0173	0.0250
CCL23	−0.4255	0.0003	−0.3546	−16.66%	<0.0001	−0.0155	0.1730
AXIN1	0.5389	0.0349	0.5611	4.12%	0.0382	0.0130	0.7345

*(Original fold change – adjusted fold change)/original fold change.

AXIN1, axin-1; CCL, C-C motif chemokine; FAP, prolyl endopeptidase; FCN2, ficolin-2; FETUB, fetuin-B; FGF21, fibroblast growth factor 21; PLTP, phospholipid transfer protein; SOD1, superoxide dismutase 1; TGFα, tranforming growth factor alfa; UMOD, uromodulin.