Table 4.
GSEA of 28 hallmark GSs, which are significantly enriched in infected primary PCPEC.
| Hallmark Gene Set Name | Size | NES | FDR q-value |
|---|---|---|---|
| TNFα signaling via NFκB | 151 | 3.12 | 0.000 |
| Interferon γ response | 135 | 2.49 | 0.000 |
| Inflammatory response | 105 | 2.48 | 0.000 |
| Allograft Rejection | 108 | 2.20 | 0.000 |
| IL6-JAK/STAT3 Signaling | 48 | 2.19 | 0.000 |
| Hypoxia | 146 | 2.12 | 0.000 |
| IL2-STAT5 Signaling | 129 | 1.99 | 0.000 |
| Interferon α response | 73 | 1.90 | 0.001 |
| Complement | 136 | 1.88 | 0.001 |
| UV response_up | 115 | 1.87 | 0.001 |
| Apoptosis | 123 | 1.85 | 0.002 |
| P53 Pathway | 154 | 1.64 | 0.016 |
| Coagulation | 78 | 1.54 | 0.034 |
| Unfolded protein response | 93 | 1.51 | 0.044 |
| Wnt/β-catenin | 31 | 1.49 | 0.047 |
| Reactive oxigen species pathway | 40 | 1.47 | 0.051 |
| Estrogen response_early | 136 | 1.41 | 0.083 |
| KRAS Signaling_up | 127 | 1.39 | 0.090 |
| Angiogenesis | 23 | 1.37 | 0.101 |
| NOTCH Signaling | 25 | 1.36 | 0.102 |
| KRAS Signaling_down | 78 | 1.28 | 0.178 |
| TGFβ Signaling | 47 | 1.27 | 0.177 |
| Xenobiotic Metabolism | 129 | 1.24 | 0.200 |
| Epithelial-Mesenchymal transition | 153 | 1.24 | 0.192 |
| Glycolysis | 145 | 1.23 | 0.195 |
| Cholesterol homeostasis | 63 | 1.23 | 0.187 |
| Androgen response | 86 | 1.23 | 0.187 |
| MTORC1 Signaling | 162 | 1.20 | 0.210 |
The normalized enrichment score (NES) represents the extent of GS enrichment, taking the number of genes (“size”), which compose the GS, into account. The false discovery rate (FDR) is considered significant if q is ≤0.25.
NES, normalized enrichment score; FDR, false discovery rate.