TABLE 2.
Ten SNPs significantly associated with the concentration ratio of 2-OH ATV to ATV in 857 patients with CAD.
| SNP | CHR | BP | Change | Gene symble | Ref | Alt | 2-OH ATV/ATV | ||
|---|---|---|---|---|---|---|---|---|---|
| Beta | P | FDR | |||||||
| rs4148323 | 2 | 234669144 | Exonic | UGT1A1 | G | A | 0.184 | 1.69E−07 | 8.66E−03 |
| rs15524 | 7 | 99245914 | UTR3 | CYP3A5 | A | G | 0.129 | 8.52E−07 | 1.09E−02 |
| rs10242455 | 7 | 99240179 | Intergenic | ZSCAN25, CYP3A5 | A | G | 0.129 | 8.52E−07 | 1.09E−02 |
| rs4646457 | 7 | 99245080 | Downstream | CYP3A5 | A | C | 0.129 | 8.52E−07 | 1.09E−02 |
| rs2687136 | 7 | 99325882 | Intronic | CYP3A7, CYP3A7-CYP3A51P | C | T | 0.125 | 2.23E−06 | 1.63E−02 |
| rs2687134 | 7 | 99331042 | Intronic | CYP3A7, CYP3A7-CYP3A51P | T | G | 0.124 | 2.29E−06 | 1.63E−02 |
| rs4646450 | 7 | 99266318 | Intronic | CYP3A5 | G | A | 0.124 | 2.60E−06 | 1.63E−02 |
| rs776746 | 7 | 99270539 | Splicing | CYP3A5 | C | T | 0.124 | 2.86E−06 | 1.63E−02 |
| rs4646458 | 7 | 99245013 | Downstream | CYP3A5 | T | G | 0.124 | 5.27E−06 | 2.70E−02 |
| rs3806598 | 2 | 234579892 | Intronic | UGT1A10, UGT1A8 | A | C | 0.151 | 7.2E−06 | 3.35E−02 |
Ref reference allele, Alt alternate allele, UTR untranslated region, SNP, single-nucleotide polymorphisms; ATV, atorvastatin; 2-OH ATV, 2-hydroxy atorvastatin; CHR, chromosome; BP, base position; FDR, false discovery rate.
The p-values were calculated based on the linear regression analysis under the additive mode. The FDR were calculated on the basis of Benjaminiand Hochberg method. The SNPs are annotated to the nearest gene if identified in this study (marked by asterisk symbol) or to previously known gene if in linkage disequilibrium with the known loci for any lipid measure. Chromosomal positions are based on hg19 reference sequence.