Figure 2.

Anti-inflammatory transcriptome modification in CM of statin-using H⁺C⁺ participants. (A) Differentially expressed genes (FDR < 0.05, |log₂FC|>1) within H⁺C⁺ participants taking statins (S⁺, n = 10) or not (S⁻, n = 13) at the time of PBMC visit, determined using edgeR. (B) Hierarchically clustered heatmap of DE genes; heatmap normalized by row z-score. Gene lists in Supplementary material online, Tables S8 and S9. DE gene list with log₂FC was used as input into Qiagen IPA core analyses. (C) Predicted regulation of canonical pathways between S⁺ and S⁻; red bar indicates activation, blue bar indicates inhibition in H⁺C⁺S⁺. All pathways shown were significantly enriched; significance calculated by right-tailed Fisher’s exact test, P < 0.05.