Figure. Outside-in-signaling by the adventitia.
Nox2-dependent secretion of GDF6 by adventitial fibroblasts mediate the vascular response to Ang II. The activation of smooth muscle cell Nox1 by GDF6 is speculative.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.