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(a) FGF23 interacting with its binary receptor complex in the orientation proposed by Yamazaki et al. where the N-terminal fragment of FGF23 interacts with FGFR and the C-terminal fragment interacts with alpha-klotho. (b) Intrinsic disorder profile of FGF23 from disopred3. (c) Residue–residue pairwise RMSD of the alpha carbons along the backbone of the refined homology models versus the FGF23 X-ray structure (PDB ID: 2P39)
